|PIN-4 Triple (Cocktail)
||P504S (AMACR) + P63 + HMW CK
||Expression of P504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It has also been found to stain premalignate lesion: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. P63 is expressed in normal prostate basal cells but is negative in malignant tumors of the prostate gland. In normal epithelia, HMW CK (34BE12) stains stratified epithelia, myoepthelia cells and basal cells in the prostate gland. Therefore, malignant glands show positive staining with P504S (AMACR) (red) and negative staining for basal cells with HMW CK and P63 (brown).